Acetanilide for Synthesis

Acetanilide for Synthesis is a high-purity grade of acetanilide (N-phenylacetamide), widely used as an intermediate and reagent in laboratory organic synthesis. It appears as a white, odorless, crystalline leaf- or flake-like solid and is selected for consistent quality in chemical research and manufacturing.​

Specification and Physical Properties

Molecular Formula: C₈H₉NO​

Purity: Typically ≥98.5% for synthesis grade​

Melting Point: 114–116°C​

Boiling Point: 304°C​

Appearance: White crystalline powder or leaf-like flakes​

Solubility: Slightly soluble in water; soluble in alcohol, acetone, and hot water​

Laboratory Applications

Synthesis Intermediate: Used in the production of dyes, rubber accelerators, pharmaceuticals (such as penicillin), and camphor.​

Teaching Labs: Classic subject for acetylation reactions and recrystallization/purification technique demonstrations.​

Reference Standard: Useful for organic qualitative analysis, controllable melting point experiments, and demonstration of amide formation.​

Research: Precursor to sulfa drugs and other aromatic amide derivatives for pharmacological testing.​

Safety and Handling

Harmful if ingested, inhaled, or absorbed through the skin; long-term exposure can damage the liver and kidneys and may cause methemoglobinemia (symptoms: bluish skin, headache, dizziness).​

Handle with gloves, goggles, and adequate ventilation; avoid eating/drinking in work areas and wash hands after use.​

Store tightly sealed in a cool, dry, labelled container.​

Acetanilide for Synthesis remains a laboratory standard for reaction experiments and industrial chemical preparation, valued for its purity, stability, and versatility.